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A Grammar for Biology
Thomas Clozel on building superintelligence that reads life
Jul 21
•
Sean Khozin, MD, MPH
5
Fifty Patients
Evidence strong enough that no one, including FDA, can object
Jul 14
•
Sean Khozin, MD, MPH
8
1
2
Everything is a Signal
The future rarely announces itself. It emerges as a collection of weak signals that most people overlook.
Jul 7
•
Sean Khozin, MD, MPH
2
June 2026
Half Full at White Oak
We hear a great deal about disruption at the FDA. We hear almost nothing about the repair underneath it, which is the part that may outlast the noise
Jun 30
•
Sean Khozin, MD, MPH
6
1
Coach K and the Human Work of Progress
A conversation about basketball, cancer, AI, and the human relationships behind progress
Jun 13
•
Sean Khozin, MD, MPH
5
42 Seconds
On daraxonrasib, the pocket that had to be invented, and what the standing ovation at ASCO really means
Jun 2
•
Sean Khozin, MD, MPH
25
1
3
May 2026
The Discipline of Precision
A Conversation with Dr. Brian Druker
May 26
•
Sean Khozin, MD, MPH
7
3
The Machinery Behind ASCO
A conversation with ASCO CEO Dr. Clifford Hudis on scientific progress, institutional memory, and AI
May 20
•
Sean Khozin, MD, MPH
4
AI in biomedicine, 2026 to 2036
Five and ten years inside the proxy machine
May 18
•
Sean Khozin, MD, MPH
14
3
2
April 2026
The Ship and the Signal
On the FDA’s real-time clinical trial initiative, the ghost of the Salisbury, and what it will take to finally retire her
Apr 28
•
Sean Khozin, MD, MPH
8
2
1
The Broken Instrument Beneath the Evidence
How the measurement substrate of oncology drug development systematically favors false negatives and why the field has not noticed
Apr 27
•
Sean Khozin, MD, MPH
10
4
The Signal We Keep Compressing Away
On automated harness optimization and what it means for clinical evidence
Apr 2
•
Sean Khozin, MD, MPH
5
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