Coach K and the Human Work of Progress

A conversation about basketball, cancer, AI, and the human relationships behind progress

Jun 13 • Sean Khozin, MD, MPH

4

42 Seconds

On daraxonrasib, the pocket that had to be invented, and what the standing ovation at ASCO really means

Jun 2 • Sean Khozin, MD, MPH

25

1

3

May 2026

The Discipline of Precision

A Conversation with Dr. Brian Druker

May 26 • Sean Khozin, MD, MPH

7

3

The Machinery Behind ASCO

A conversation with ASCO CEO Dr. Clifford Hudis on scientific progress, institutional memory, and AI

May 20 • Sean Khozin, MD, MPH

4

AI in biomedicine, 2026 to 2036

Five and ten years inside the proxy machine

May 18 • Sean Khozin, MD, MPH

12

3

1

April 2026

The Ship and the Signal

On the FDA’s real-time clinical trial initiative, the ghost of the Salisbury, and what it will take to finally retire her

Apr 28 • Sean Khozin, MD, MPH

8

2

1

The Broken Instrument Beneath the Evidence

How the measurement substrate of oncology drug development systematically favors false negatives and why the field has not noticed

Apr 27 • Sean Khozin, MD, MPH

10

4

The Signal We Keep Compressing Away

On automated harness optimization and what it means for clinical evidence

Apr 2 • Sean Khozin, MD, MPH

5

March 2026

The Simulator’s Dilemma, Revisited

Notes from the NCI Foundation Models for Cancer Workshop, March 26, 2026

Mar 27 • Sean Khozin, MD, MPH

7

3

Asking the Right Questions

What a refugee camp, a cancer center, and AstraZeneca's oncology franchise have in common

Mar 25 • Sean Khozin, MD, MPH

2

1

February 2026

The Last Interview

On what it means to ask a machine if it is afraid to die

Feb 26 • Sean Khozin, MD, MPH

5

1

When the Cure Already Exists

A conversation with David Fajgenbaum on drug repurposing, rare disease, and why the answers might already be on the shelf

Feb 20 • Sean Khozin, MD, MPH

18

4

4