From Mysticism to Standard of Care

Jedd Wolchok and what cancer immunotherapy taught us about recognizing progress

Oct 15 • Sean Khozin, MD, MPH

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A Thousand Runs

What FDA’s generative AI discussion paper reveals about machines, clinicians, and the standard of care

Oct 14 • Sean Khozin, MD, MPH

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Waiting for Frances Kelsey

Why the FDA does not need more reviewers and what it needs instead

Oct 3 • Sean Khozin, MD, MPH

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August 2026

Ideas That Refuse to Die

Peter Kolchinsky on biotech, AI, clinical trials, and the responsibility to lead

Aug 27 • Sean Khozin, MD, MPH

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The Signals Beneath the Noise

Precision Signals, one year in

Aug 10 • Sean Khozin, MD, MPH

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July 2026

A Grammar for Biology

Thomas Clozel on building superintelligence that reads life

Jul 21 • Sean Khozin, MD, MPH

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Fifty Patients

Evidence strong enough that no one, including FDA, can object

Jul 14 • Sean Khozin, MD, MPH

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Everything is a Signal

The future rarely announces itself. It emerges as a collection of weak signals that most people overlook.

Jul 7 • Sean Khozin, MD, MPH

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June 2026

Half Full at White Oak

We hear a great deal about disruption at the FDA. We hear almost nothing about the repair underneath it, which is the part that may outlast the noise

Jun 30 • Sean Khozin, MD, MPH

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Coach K and the Human Work of Progress

A conversation about basketball, cancer, AI, and the human relationships behind progress

Jun 13 • Sean Khozin, MD, MPH

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42 Seconds

On daraxonrasib, the pocket that had to be invented, and what the standing ovation at ASCO really means

Jun 2 • Sean Khozin, MD, MPH

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May 2026

The Discipline of Precision

A Conversation with Dr. Brian Druker

May 26 • Sean Khozin, MD, MPH

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